Purchased in 1972 by John Cushman and five friends, Zaca Mesa's first vines were planted a year later. Only the third winery in Santa Barbara County at that time, Zaca Mesa became a Santa Barbara County "vineyard wildcatter" - experimenting with many varietals, including Cabernet Sauvignon, Merlot, Zinfandel, Riesling, Pinot Noir, Sauvignon Blanc, Chenin Blanc, and Chardonnay to see what would work. After several years of trial and error, Syrah was planted in 1978. Unbeknownst to the early winemaking team at the time, this block would become what is today the renown Black Bear Block, the oldest Syrah block in the Central Coast.

As a vineyard and winery pioneer in the Santa Barbara County, Zaca Mesa also became the training ground for many great winemakers. Ken Brown was Zaca Mesa's first winemaker who later started Byron in Santa Maria Valley. Adam Tolmach, Jim Clendenen and Bob Lindquist worked at Zaca Mesa before venturing out on their own to start Ojai, Au Bon Climat and Qupé, respectively. The number of winemakers that got their start at Zaca Mesa helped create what is now affectionately known as "Zaca University."

The first Central Coast wine to achieve a Wine Spectator Top Ten was the 1993 Zaca Mesa Syrah, which came in at #6 and was the creation of winemaker Daniel Gehrs. This wine was also the wine of choice served at the White House in 1996 for the French President Jacques Chirac official State Dinner.

Zaca Mesa's vineyards is too far inland from the coast to produce quality Pinot Noir, and not quite hot enough to produce quality Cabernet Sauvignon, but they turned out to be ideal for Rhone Varietals. The soil, climate, and altitude of the Zaca Mesa vineyards were great not only for Syrah, but also for Roussanne, Viognier, Grenache, Mourvedre, Cinsaut, and Grenache Blanc which were planted in the 1990's and 2000's.

Since 1997, the vineyard and winemaking practices have focused on growing the best Syrah, Viognier, and other Rhône varieties. Zaca Mesa has ripped out over half the original vines, and replaced them with high-density plantings of new rootstock and clone combinations to significantly improve quality. The result is Zaca Mesa wines consistently receive high scores and praise industry wide.